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Efficacy Data: Response rate: Not reported Remission rate: Not reported MADRS change: -6.6 points (D-cycloserine) vs -2.8 points (placebo) at 6 weeks (in TRD) Time to response: 2-6 weeks Source Why it might interest you: Different mechanism (NMDA modulation), potential for fewer side effects, and may benefit those who do not tolerate or respond to standard antidepressants